Tackling Poor Egg Quality

“A shocking wealth of reproductive physiology knowledge.” – Subodh Chauhan, MD

“Ingenious physiological insight into even the most difficult cases.”  – Botros Rizk, MD

“Indispensable when deciphering my poor egg quality cases.” – Michael Allon, MD

Bridging Research and Clinical Expertise with Term Stim™

Each poor egg quality case is unique and, in effect, a research project focused on a single patient. Translational Fertility adds reproductive-physiology research expertise and tools to complement physician’s clinical judgment, deepen the understanding of the case, and help create and carry out a fully customized service – Term Stim™.

New Physiology of Reproductive Cycle

Dozortsev and Diamond, Fert Stert, 2020
Translational Fertility was created to assist physicians in incorporating the latest insights from reproductive research into clinical practice. Our cornerstone is the New Ovulation Paradigm recognized by Fertility and Sterility as a “Sea Change in Reproductive Physiology” in 2020. This paradigm has reshaped the view of the reproductive cycle and identified new entry points for controlling egg quality.
It offers a unifying framework for phenomena that remained unresolved for decades:
  • The variability and age-related shortening of the menstrual cycle.
  • The consistency of single-egg, random side ovulation.
  • The link between vanishing follicles and post-mature oocytes.
  • The impact of follicular-phase duration on egg quality.
  • The underlying mechanisms of reproductive aging and PCOS.
This research introduced the concept of Term Maturation™—the principle that an oocyte requires a minimum “term” of development to reach full competence. Early clinical evidence and published case reports now support this as a new standard for improving IVF outcomes.

Patents and Publications

Progesterone is a physiological trigger of ovulatory gonadotropins. Dozortsev D, Pellicer A, Diamond MP. Fertil Steril. 2020 May;113(5):923-924. doi: 10.1016/j.fertnstert.2019.12.024. Epub 2020 Feb 12. PMID: 32059812

Two peas from the same pod: vanishing follicles and postmature oocytes. Dozortsev DI, Diamond MP. Fertil Steril. 2022 Jan;117(1):40-41. doi: 10.1016/j.fertnstert.2021.09.027. Epub 2021 Nov 6. PMID: 34753599

Premature progesterone rise as a trigger of polycystic ovarian syndrome. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Nov;114(5):943-944. doi: 10.1016/j.fertnstert.2020.07.007. Epub 2020 Oct 6. PMID: 33036794

Term oocyte maturation and term ovarian stimulation: impact on oocyte competence. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Aug;114(2):221-222. doi: 10.1016/j.fertnstert.2020.04.013. Epub 2020 Jul 1. PMID: 32622662

Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2021 Sep;116(3):630-632. doi: 10.1016/j.fertnstert.2021.05.107. Epub 2021 Jul 22. PMID: 34303510

Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Dozortsev DI, Diamond MP. Fertil Steril. 2020 Aug;114(2):191-199. doi: 10.1016/j.fertnstert.2020.06.016. PMID: 32741458

Ovulation and birth after administration of progesterone trigger-two case reports. Villar L, Tralik B, Diamond MP, Allon M, Maldonado I, Dozortsev DI. J Assist Reprod Genet. 2023 May;40(5):1037-1044. doi: 10.1007/s10815-023-02750-x. Epub 2023 Feb 20. PMID: 36808579

Term Stimulation – two case reports. Villar L, Diamond MP, Maldonado I, Dozortsev D. Journal of IVF-Worldwide. 2023;1(1-3).
Disclaimer: The information provided is not intended as medical advice. Translational Fertility LLC offers consulting and advisory services in reproductive physiology exclusively to participating physicians, who are fully licensed in their respective jurisdictions and who retain full clinical discretion and control over the diagnosis, care, and treatment of their patients.