Progymax™

REPURPOSING OF PROGESTERONE FOR TRIGERRING OVULATION

US and International Patents Pending . Co-Invented with Michael P. Diamond, MD of Augusta University

The Problem: Artificial Luteal Phase is Suboptimal

Discovery

Prediction and Protocol

Case report

Case report

Potential Benefits

Patent

Publications

Progesterone is a physiological trigger of ovulatory gonadotropins. Dozortsev D, Pellicer A, Diamond MP. Fertil Steril. 2020 May;113(5):923-924. doi: 10.1016/j.fertnstert.2019.12.024. Epub 2020 Feb 12. PMID: 32059812

Two peas from the same pod: vanishing follicles and postmature oocytes. Dozortsev DI, Diamond MP. Fertil Steril. 2022 Jan;117(1):40-41. doi: 10.1016/j.fertnstert.2021.09.027. Epub 2021 Nov 6. PMID: 34753599

Premature progesterone rise as a trigger of polycystic ovarian syndrome. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Nov;114(5):943-944. doi: 10.1016/j.fertnstert.2020.07.007. Epub 2020 Oct 6. PMID: 33036794

Term oocyte maturation and term ovarian stimulation: impact on oocyte competence. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Aug;114(2):221-222. doi: 10.1016/j.fertnstert.2020.04.013. Epub 2020 Jul 1. PMID: 32622662

Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2021 Sep;116(3):630-632. doi: 10.1016/j.fertnstert.2021.05.107. Epub 2021 Jul 22. PMID: 34303510

Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Dozortsev DI, Diamond MP. Fertil Steril. 2020 Aug;114(2):191-199. doi: 10.1016/j.fertnstert.2020.06.016. PMID: 32741458

Ovulation and birth after administration of progesterone trigger-two case reports. Villar L, Tralik B, Diamond MP, Allon M, Maldonado I, Dozortsev DI. J Assist Reprod Genet. 2023 May;40(5):1037-1044. doi: 10.1007/s10815-023-02750-x. Epub 2023 Feb 20. PMID: 36808579

Term Stimulation – two case reports. Villar L, Diamond MP, Maldonado I, Dozortsev D. Journal of IVF-Worldwide. 2023;1(1-3).