Term Stim™
Term Stim™ is a patents-pending, HIPAA-compliant SaaS ovarian stimulation management platform powered by a railed AI decision-support engine with a closed-loop feedback architecture. It is designed to analyze the integrity of the ovarian cycle as a coordinated system – from follicular development through ovulation and luteal function – in order to assist physicians in managing difficult reproductive cases, including poor egg quality and failed frozen embryo transfers.
Term Stim™ assists physicians in creating and executing a treatment strategy for patients who have already failed ovarian stimulation due to poor egg quality. It is not only a research tool, but is also capable providing step-by-step reproductive physiology recommendations using proprietary knowledge base and the totality of the patient’s history, diagnostic cycle, and current cycle data.
Limited Use of AI
In medicine, AI is very successful at searching for and applying a template that worked for a similar patient. But in cases of poor egg quality, this approach is rarely fruitful, since each case is unique. Therefore, in Term Stim™, we use AI only to help track relevant variables and identify subtle trends in a patient’s data that might otherwise be overlooked. However, all validation, interpretation, and recommendations remain entirely human – grounded in research, experience, and expertise.
Designed for Research and Collaboration
Diagnostic Cycle
For routine IVF, granular cycle data is rarely actionable. For complex cases, however, a detailed physiologic study is essential. Therefore every Term Stim™ engagement begins with a diagnostic cycle – about one month of structured monitoring – to map the patient’s reproductive dynamics, identify potential contributors to poor egg quality, and generate guidance for the subsequent treatment cycle.
For example, you may find that a patient’s follicles begin to luteinize at 16 mm (not 18 mm), with progesterone rising from 0.1 ng/mL to 0.4 ng/mL. This points to the need for a pre-emptive trigger and helps determine whether premature luteinization affects one follicle or the entire cohort.
It also gives an opportunity to test and quantify the patient’s response to medications planned for treatment. For instance, we confirm whether FSH kinetics follow the expected compounding profile; if not, we help you define dose and timing adjustments.
When appropriate, the diagnostic cycle can transition directly into treatment – for example, if an unexpectedly well-synchronized cohort is observed after an LH surge.
Treatment Cycle
The board: A structured case board (timeline + variable panes) that shows the whole case at a glance.
The pieces: Growth tempo, cohort synchrony, historic and current FSH, P4, E2 and LH trends , micro P4 drift, E2–size concordance, prior cycle kinetics, looks backs, medication states, etc.
The rules: Latest reproductive physiology, proprietary and patent pending
algorithms, protocol preferences, evidence weighting etc.
Briefs: Step-by-step briefs, based on evidence driven synthesis, that you can review in under a minute.
For essential data entry you and staff members can use our mobile app with very intuitive interface.
The Term Stim™ platform enables physicians to deliver previously unattainable level of care to their patients as a premium service.
Evidence driven synthesis. Case specific briefs.
Publications
Progesterone is a physiological trigger of ovulatory gonadotropins. Dozortsev D, Pellicer A, Diamond MP. Fertil Steril. 2020 May;113(5):923-924. doi: 10.1016/j.fertnstert.2019.12.024. Epub 2020 Feb 12. PMID: 32059812
Two peas from the same pod: vanishing follicles and postmature oocytes. Dozortsev DI, Diamond MP. Fertil Steril. 2022 Jan;117(1):40-41. doi: 10.1016/j.fertnstert.2021.09.027. Epub 2021 Nov 6. PMID: 34753599
Premature progesterone rise as a trigger of polycystic ovarian syndrome. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Nov;114(5):943-944. doi: 10.1016/j.fertnstert.2020.07.007. Epub 2020 Oct 6. PMID: 33036794
Term oocyte maturation and term ovarian stimulation: impact on oocyte competence. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2020 Aug;114(2):221-222. doi: 10.1016/j.fertnstert.2020.04.013. Epub 2020 Jul 1. PMID: 32622662
Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans. Dozortsev DI, Pellicer A, Diamond MP. Fertil Steril. 2021 Sep;116(3):630-632. doi: 10.1016/j.fertnstert.2021.05.107. Epub 2021 Jul 22. PMID: 34303510
Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Dozortsev DI, Diamond MP. Fertil Steril. 2020 Aug;114(2):191-199. doi: 10.1016/j.fertnstert.2020.06.016. PMID: 32741458
Ovulation and birth after administration of progesterone trigger-two case reports. Villar L, Tralik B, Diamond MP, Allon M, Maldonado I, Dozortsev DI. J Assist Reprod Genet. 2023 May;40(5):1037-1044. doi: 10.1007/s10815-023-02750-x. Epub 2023 Feb 20. PMID: 36808579
Term Stimulation – two case reports. Villar L, Diamond MP, Maldonado I, Dozortsev D. Journal of IVF-Worldwide. 2023;1(1-3).
